2026
Sanchez-Velasquez J., Sun T., Zhang X. &
Hinde E. Spatial Triple-Correlation Spectroscopy (S3CS) Reveals Heterotrimer Dynamics in Live Cells.
Biophysical Journal 2026.
DOI:
10.1016/j.bpj.2026.03.007
2025
Sanchez-Velasquez J., Solano A., Digman M.A., Gratton E., Cardarelli F. &
Hinde E. Pair correlation microscopy of intracellular molecular transport.
Nat Protoc. 2025. 10: 1651–1677.
DOI:
10.1038/s41596-024-01097-6
2024
Lou J., Deng Q., Zhang, X., Bell C.C., Das A.B., Bediaga N.G., Zlatic C.O., Johanson T.M., Allan R.S., Griffin M.D.W., Paradkar P., Harvey K.F., Dawson M.A. &
Hinde E. Heterochromatin protein 1 alpha (HP1α) undergoes a monomer to dimer transition that opens and compacts live cell genome architecture.
Nucleic Acids Research 2024. 52(18): 10918-10933.
DOI:
10.1093/nar/gkae720
Lian Z., Solano A., Lou J. &
Hinde E. Histone FRET reports the spatial heterogeneity in nanoscale chromatin architecture that is imparted by the epigenetic landscape at the level of single foci in an intact cell nucleus.
Chromosoma 2024. 133(1): 5-14.
DOI:
10.1007/s00412-024-00815-z
Mehl B.P., Vairaprakash P., Li L.,
Hinde E., MacNevin C.J., Hsu C., Gratton E., Liu B. & Hahn K.M. Live-cell biosensors based on the fluorescence lifetime of environment-sensing dyes.
Cell Reports Methods 2024. 4(3): 100734.
DOI:
10.1016/j.crmeth.2024.100734
2023
Owyong T.C., O’Shea R., Lee M., White J.M., Donnelly P.S.,
Hinde E., Wong W.W.H. & Hong Y. A General Fluorescence-Based Method for Quantifying and Mapping Biomolecular Polarity In Vitro and In Cells.
bioRxiv 2023.
DOI:
10.1101/2023.02.07.526546
2022
Solano A., Lou J., Scipioni L., Gratton E. &
Hinde E.. Radial pair correlation of molecular brightness fluctuations maps protein diffusion as a function of oligomeric state within live-cell nuclear architecture.
Biophysical Journal 2022. 122(11): 2152-2167.
DOI:
10.1016/j.bpj.2022.04.030
Mitrentsi, I., Lou J., Kerjouan A., Verigos J., Reina-San-Martin B.,
Hinde E. & Soutoglou E. Heterochromatic repeat clustering imposes a physical barrier on homologous recombination to prevent chromosomal translocations.
Mol Cell. 2022. 82(11): 2132–2147.e6
DOI:
10.1016/j.molcel.2022.03.033
Deore P., Wanigasuriya I., Tsang Min Ching S.J., Brumley D.R., van Oppen M.J.H., Blackall L.L. &
Hinde E.. Fluorescence lifetime imaging microscopy (FLIM): a non-traditional approach to study host-microbial symbioses.
Micriobiol Aust. 2022. 43(1): 22-27
DOI:
10.1071/MA22008
2021
Lou J., Solano A., Liang Z. &
Hinde E.. Phasor Histone FLIM-FRET Microscopy Maps Nuclear-Wide Nanoscale Chromatin Architecture With Respect to Genetically Induced DNA Double-Strand Breaks.
Front Genet. 2021. 12: 770081.
DOI:
10.3389/fgene.2021.770081
Priest D.J., Bernardini A., Lou J., Mantovani R. &
Hinde E.. Live cell dynamics of the NF-Y transcription factor.
Sci Rep. 2021. 11: 10992
DOI:
10.1038/s41598-021-90081-1
Wesemann L., Rickett J., Song J., Lou J.,
Hinde E., Davis T.J. & Roberts A. Nanophotonics enhanced coverslip for phase imaging in biology.
Light Sci Appl. 2021. 10: 98
DOI:
10.1038/s41377-021-00540-7
Palmer C.S., Lou J., Kouskousis B., Pandzic E., Anderson A.J., Kang Y.,
Hinde E. & Stojanovski D. Super-resolution microscopy reveals the arrangement of inner membrane protein complexes in mammalian mitochondria.
J Cell Sci. 2021. 134(13): jcs252197.
DOI:
10.1242/jcs.252197
2020
Lou J., Priest D.G., Solano A., Kerjouan A. &
Hinde E.. Spatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break.
Nat Commun. 2020. 11(1): 5776.
DOI:
10.1038/s41467-020-19504-3
Liang Z., Lou J., Scipioni L., Gratton E. &
Hinde E.. Quantifying nuclear wide chromatin compaction by phasor analysis of histone Förster resonance energy transfer (FRET) in frequency domain fluorescence lifetime imaging microscopy (FLIM) data.
Data Brief 2020. 30: 105401.
DOI:
10.1016/j.dib.2020.105401
2019
Priest D.J., Solano A., Lou J. &
Hinde E.. Fluorescence fluctuation spectroscopy: an invaluable microscopy tool for uncovering the biophysical rules for navigating the nuclear landscape.
Biochem Soc Trans. 2019. 47(4):1117-1129.
DOI:
10.1042/BST20180604
Lou J., Khor J., Priest D. &
Hinde E.. Fluorescence Fluctuation Spectroscopy Reveals Double Strand Break Recruitment of 53BP1 Dimers and Assembly into Higher-Order Oligomers at the DNA Repair Locus.
Biophysical Journal. 2019. 116(3)
DOI:
10.1016/j.bpj.2018.11.156
Lou J., Scipioni L., Wright B.K. &
Hinde E.. Phasor histone FLIM-FRET microscopy quantifies spatiotemporal rearrangement of chromatin architecture during the DNA damage response.
Proceedings of the National Academy of Sciences. 2019. 116(15): 7323-7332
DOI:
10.1073/pnas.1814965116
2017
Hinde E., Thammasiraphop K., Duong H.T.T., Yeow J., Karagoz B., Boyer C., Gooding J. & Gaus K. Pair correlation microscopy reveals the role of nanoparticle shape in intracellular transport and site of drug release.
Nature Nanotech. 2017. 12: 81–89.
DOI:
10.1038/nnano.2016.160
2016
Hinde E., Pandžić E., Yang Z., Ng I.H.W., Jans D.A., Bogoyevitch M.A., Gratton E. & Gaus K. Quantifying the dynamics of the oligomeric transcription factor STAT3 by pair correlation of molecular brightness.
Nat Commun. 2016. 7: 11047.
DOI:
10.1038/ncomms11047
2015-2014
Hinde E., Cardarelli F. & Gratton E. Spatiotemporal regulation of Heterochromatin Protein 1-alpha oligomerization and dynamics in live cells.
Sci Rep. 2015. 5: 12001.
DOI:
10.1038/srep12001
Hinde E., Kong X., Yokomori K. & Gratton E. Chromatin dynamics during DNA repair revealed by pair correlation analysis of molecular flow in the nucleus.
Biophys J. 2014. 107(1): 55-65.
DOI:
10.1016/j.bpj.2014.05.027
